A Novel Dermaseptin Isolated from the Skin Secretion of Phyllomedusa tarsius and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities

A novel dermaseptin peptide, dermaseptin-PT9 (DPT9), was isolated and identified from Phyllomedusa tarsius by the combination of molecular cloning and LC-MS analysis. Chemically synthesised DPT9 was broadly effective against the tested microorganisms through the disruption of cell membranes and show...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Li, Miaoran, Xi, Xinping, Ma, Chengbang, Chen, Xiaoling, Zhou, Mei, Burrows, James F., Chen, Tianbao, Wang, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6843903/
https://ncbi.nlm.nih.gov/pubmed/31635388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9100628
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