The Loss-of-Function S267F Variant in HBV Receptor NTCP Reduces Human Risk for HBV Infection and Disease Progression

BACKGROUND: Sodium taurocholate cotransporting polypeptide (NTCP, SLC10A1) is a hepatocyte receptor for hepatitis B virus (HBV) infection. The natural NTCP S267F variant causes loss of NTCP HBV receptor function. We assessed the association of S267F with HBV resistance, HBV infection clearance, and...

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Bibliographic Details
Published in:J Infect Dis
Main Authors: An, Ping, Zeng, Zheng, Winkler, Cheryl A
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Major Articles and Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151084/
https://ncbi.nlm.nih.gov/pubmed/29905807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy355
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