TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation

BACKGROUND: TEM8 is a cell membrane protein predominantly expressed in tumor endothelium, which serves as a receptor for the protective antigen (PA) of anthrax toxin. However, the physiological ligands for TEM8 remain unknown. RESULTS: Here we identified uPA as an interacting partner of TEM8. Bindin...

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Bibliografiske detaljer
Udgivet i:Cell Commun Signal
Main Authors: Zhang, Lian-Cheng, Shao, Yong, Gao, Li-Hua, Liu, Jin, Xi, Yong-Yi, Xu, Yin, Wu, Chutse, Chen, Wei, Chen, Hui-Peng, Wang, You-Liang, Duan, Hai-Feng, Hu, Xian-Wen
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151050/
https://ncbi.nlm.nih.gov/pubmed/30241478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-018-0272-8
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