BayesCCE: a Bayesian framework for estimating cell-type composition from DNA methylation without the need for methylation reference

We introduce a Bayesian semi-supervised method for estimating cell counts from DNA methylation by leveraging an easily obtainable prior knowledge on the cell-type composition distribution of the studied tissue. We show mathematically and empirically that alternative methods which attempt to infer ce...

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Publicat a:Genome Biol
Autors principals: Rahmani, Elior, Schweiger, Regev, Shenhav, Liat, Wingert, Theodora, Hofer, Ira, Gabel, Eilon, Eskin, Eleazar, Halperin, Eran
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Method
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151042/
https://ncbi.nlm.nih.gov/pubmed/30241486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1513-2
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