CONFINED: distinguishing biological from technical sources of variation by leveraging multiple methylation datasets

Methylation datasets are affected by innumerable sources of variability, both biological (cell-type composition, genetics) and technical (batch effects). Here, we propose a reference-free method based on sparse canonical correlation analysis to separate the biological from technical sources of varia...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Genome Biol
Autori principali: Thompson, Mike, Chen, Zeyuan Johnson, Rahmani, Elior, Halperin, Eran
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624895/
https://ncbi.nlm.nih.gov/pubmed/31300005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1743-y
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