Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice

BACKGROUND: We recently identified a role for the muscle-specific ubiquitin ligase MuRF1 in right-sided heart failure secondary to pulmonary hypertension induced by chronic hypoxia (CH). MuRF1−/− mice exposed to CH are resistant to right ventricular (RV) dysfunction whereas MuRF1 Tg + mice exhibit i...

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Vydáno v:BMC Med Genet
Hlavní autoři: Oakley, Robert H., Campen, Matthew J., Paffett, Michael L., Chen, Xin, Wang, Zhongjing, Parry, Traci L., Hillhouse, Carolyn, Cidlowski, John A., Willis, Monte S.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150973/
https://ncbi.nlm.nih.gov/pubmed/30241514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12881-018-0670-1
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