N-terminal α-amino group modification of antibodies using a site-selective click chemistry method

Site-specific conjugation of small molecules to antibody molecules is a promising strategy for generation of antibody-drug conjugates. In this report, we describe the successful synthesis of a novel bifunctional molecule, 6-(azidomethyl)-2-pyridinecarboxyaldehyde (6-AM-2-PCA), which was used for con...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Li, De-zhi, Han, Bing-nan, Wei, Rui, Yao, Gui-yang, Chen, Zhizhen, Liu, Jie, Poon, Terence C.W., Su, Wu, Zhu, Zhongyu, Dimitrov, Dimiter S., Zhao, Qi
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150616/
https://ncbi.nlm.nih.gov/pubmed/29652547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1463122
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