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Strain-promoted “click” chemistry for terminal labeling of DNA

1,3-Dipolar [3+2] cycloaddition between azides and alkynes—an archetypal “click” chemistry—has been used increasingly for the functionalization of nucleic acids. Copper(I)-catalyzed 1,3-dipolar cycloaddition reactions between alkyne-tagged DNA molecules and azides work well, but they require optimiz...

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Detalhes bibliográficos
Main Authors: Marks, Isaac S., Kang, Jun Sung, Jones, Brady T., Landmark, Kevin J., Cleland, Andrew J., Taton, T. Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622500/
https://ncbi.nlm.nih.gov/pubmed/21539391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc1003668
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