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Strain-promoted “click” chemistry for terminal labeling of DNA
1,3-Dipolar [3+2] cycloaddition between azides and alkynes—an archetypal “click” chemistry—has been used increasingly for the functionalization of nucleic acids. Copper(I)-catalyzed 1,3-dipolar cycloaddition reactions between alkyne-tagged DNA molecules and azides work well, but they require optimiz...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3622500/ https://ncbi.nlm.nih.gov/pubmed/21539391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc1003668 |
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