Synthesis and In Vitro Antiproliferative Activity of 11-Substituted Neocryptolepines with a Branched ω-Aminoalkylamino Chain

Neocryptolepine, which is a kind of tetracyclic indoloquinoline alkaloid, exhibits the inhibition of topoisomerase II and shows antiproliferative activity. The present study describes the synthesis and antiproliferative evaluation of several neocryptolepine analogues carrying a branched, functionali...

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Veröffentlicht in:Molecules
Hauptverfasser: Shaban, Elkhabiry, Świtalska, Marta, Wang, Li, Wang, Ning, Xiu, Fan, Hayashi, Ikuya, Ngoc, Tran Anh, Nagae, Sachie, El-Ghlban, Samah, Shimoda, Shiho, El Gokha, Ahmed Abdel Aleem, El Sayed, Ibrahim El Tantawy, Wietrzyk, Joanna, Inokuchi, Tsutomu
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150407/
https://ncbi.nlm.nih.gov/pubmed/29137152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22111954
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