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The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth

The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation. Here we discuss the potential impact of splicing-mo...

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Vydáno v:Mol Cell Oncol
Hlavní autoři: Kim, Jeongkyu, Oberdoerffer, Philipp, Khurana, Simran
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149989/
https://ncbi.nlm.nih.gov/pubmed/30250894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1441629
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