Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model

Isoform selection of pyruvate kinase M (PKM), a glycolytic enzyme, influences fates of glucose-derived carbons in cellular metabolic networks. We recently developed novel mouse lines to study PKM isoform function and identified PKM1 as a potential target in a subset of human lung cancers. This work...

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Published in:Mol Cell Oncol
Main Authors: Sato, Taku, Morita, Mami, Nomura, Miyuki, Tanuma, Nobuhiro
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149909/
https://ncbi.nlm.nih.gov/pubmed/30250920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1472054
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