An unexpected tumor suppressor role for VAV1(a)

RHO GDP/GTP exchange factors, including VAV1, are considered key protumorigenic factors. Against this paradigm, we have found that VAV1 plays tumor suppressor roles by buffering NOTCH1 signals in thymocytes. The silencing of this pathway contributes to the pathogenesis of T cell acute lymphoblastic...

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Publicado en:Mol Cell Oncol
Main Authors: Bustelo, Xosé R., Lorenzo-Martín, L. Francisco, Cuadrado, Myriam, Fernández-Pisonero, Isabel, Robles-Valero, Javier
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6149884/
https://ncbi.nlm.nih.gov/pubmed/30250888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1432257
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