A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia

Rho guanine exchange factors (GEFs), the enzymes that stimulate Rho GTPases, are deemed as potential therapeutic targets owing to their protumorigenic functions. However, the understanding of the spectrum of their pathobiological roles in tumors is still very limited. We report here that the GEF Vav...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Robles-Valero, Javier, Lorenzo-Martín, L. Francisco, Menacho-Márquez, Mauricio, Fernández-Pisonero, Isabel, Abad, Antonio, Camós, Mireia, Toribio, María L., Espinosa, Lluis, Bigas, Anna, Bustelo, Xosé R.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691892/
https://ncbi.nlm.nih.gov/pubmed/29136506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.10.004
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