Inference of Germline Mutational Status and Evaluation of Loss of Heterozygosity in High-Depth, Tumor-Only Sequencing Data

PURPOSE: Inherited germline defects are implicated in up to 10% of human tumors, with particularly well-known roles in breast and ovarian cancers that harbor BRCA1/2-mutated genes. There is also increasing evidence for the role of germline alterations in other malignancies such as colon and pancreat...

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Udgivet i:JCO Precis Oncol
Main Authors: Khiabanian, Hossein, Hirshfield, Kim M., Goldfinger, Mendel, Bird, Simon, Stein, Mark, Aisner, Joseph, Toppmeyer, Deborah, Wong, Serena, Chan, Nancy, Dhar, Kalyani, Gheeya, Jinesh, Vig, Hetal, Hadigol, Mohammad, Pavlick, Dean, Ansari, Sepand, Ali, Siraj, Xia, Bing, Rodriguez-Rodriguez, Lorna, Ganesan, Shridar
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2018
Fag:
Original Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148761/
https://ncbi.nlm.nih.gov/pubmed/30246169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.17.00148
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