Inference of Germline Mutational Status and Evaluation of Loss of Heterozygosity in High-Depth, Tumor-Only Sequencing Data

PURPOSE: Inherited germline defects are implicated in up to 10% of human tumors, with particularly well-known roles in breast and ovarian cancers that harbor BRCA1/2-mutated genes. There is also increasing evidence for the role of germline alterations in other malignancies such as colon and pancreat...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Khiabanian, Hossein, Hirshfield, Kim M., Goldfinger, Mendel, Bird, Simon, Stein, Mark, Aisner, Joseph, Toppmeyer, Deborah, Wong, Serena, Chan, Nancy, Dhar, Kalyani, Gheeya, Jinesh, Vig, Hetal, Hadigol, Mohammad, Pavlick, Dean, Ansari, Sepand, Ali, Siraj, Xia, Bing, Rodriguez-Rodriguez, Lorna, Ganesan, Shridar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2018
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148761/
https://ncbi.nlm.nih.gov/pubmed/30246169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.17.00148
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