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Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4(CRBN) activity
Lenalidomide mediates the ubiquitination and degradation of Ikaros family zinc finger protein 1 (IKZF1), IKZF3, and casein kinase 1α (CK1α) by facilitating their interaction with cereblon (CRBN), the substrate receptor for the CRL4(CRBN) E3 ubiquitin ligase. Through this mechanism, lenalidomide is a...
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| Pubblicato in: | Blood |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6148446/ https://ncbi.nlm.nih.gov/pubmed/30042095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-01-821769 |
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