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Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics
Methadone is a synthetic, long-acting opioid with a single chiral center forming two enantiomers, (R)-methadone and (S)-methadone, each having specific pharmacological actions. Concentrations of (R)- and (S)-methadone above therapeutic levels have the ability to cause serious, life-threatening, and...
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| Veröffentlicht in: | Biochem Pharmacol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6148365/ https://ncbi.nlm.nih.gov/pubmed/29458047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.02.020 |
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