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Immobilized Cytochrome P450 for Monitoring of P450-P450 Interactions and Metabolism

Cytochrome P450 (P450) protein-protein interactions have been shown to alter their catalytic activity. Furthermore, these interactions are isoform specific and can elicit activation, inhibition, or no effect on enzymatic activity. Studies show that these effects are also dependent on the protein par...

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Publicado en:Drug Metab Dispos
Autores principales: Bostick, Chris D., Hickey, Katherine M., Wollenberg, Lance A., Flora, Darcy R., Tracy, Timothy S., Gannett, Peter M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851305/
https://ncbi.nlm.nih.gov/pubmed/26961240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.067637
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