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Identification of a Transthyretin Enhancer Site That Selectively Binds the Hepatocyte Nuclear Factor-3β Isoform

The upstream proximal region of the transthyretin (TTR) promoter and a distal enhancer are sufficient to drive liver-specific expression of the TTR gene, as demonstrated by experiments in transgenic mice. Previous analyses have characterized the binding of a number of liver-enriched transcription fa...

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Publicado en:Gene Expr
Main Authors: Samadani, Uzma, Qian, Xiaobing, Costa, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado: Cognizant Communication Corporation 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148260/
https://ncbi.nlm.nih.gov/pubmed/8931989
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