Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling

Hypoxia is beneficial for the differentiation of stem cells transplanted for myocardial injury, but mechanisms underlying this benefit remain unsolved. Here, we report the impact of hypoxia-induced Jagged1 expression in cardiomyocytes (CMs) for driving the differentiation of cardiac stem cells (CSCs...

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Veröffentlicht in:Acta Pharm Sin B
Hauptverfasser: Wang, Keke, Ding, Ranran, Ha, Yanping, Jia, Yanan, Liao, Xiaomin, Wang, Sisi, Li, Rujia, Shen, Zhihua, Xiong, Hui, Guo, Junli, Jie, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
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Original article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148082/
https://ncbi.nlm.nih.gov/pubmed/30245966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2018.06.003
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