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Polybrene induces neural degeneration by bidirectional Ca(2+) influx-dependent mitochondrial and ER–mitochondrial dynamics
Hexadimethrine bromide (Polybrene) was once used clinically as a heparin neutralizer and has recently found use as a promoter in virus-mediated gene therapy trials and gene transfer in research. However, the potential for tissue-specific toxicity of polybrene at low doses has been ignored so far. He...
Gardado en:
| Publicado en: | Cell Death Dis |
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| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6148003/ https://ncbi.nlm.nih.gov/pubmed/30237514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1009-8 |
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