Polybrene induces neural degeneration by bidirectional Ca(2+) influx-dependent mitochondrial and ER–mitochondrial dynamics

Hexadimethrine bromide (Polybrene) was once used clinically as a heparin neutralizer and has recently found use as a promoter in virus-mediated gene therapy trials and gene transfer in research. However, the potential for tissue-specific toxicity of polybrene at low doses has been ignored so far. He...

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Vydáno v:Cell Death Dis
Hlavní autoři: Bao, Feixiang, Shi, Hongyan, Gao, Mi, Yang, Liang, Zhou, Lingyan, Zhao, Qiuge, Wu, Yi, Chen, Keshi, Xiang, Ge, Long, Qi, Guo, Jingyi, Zhang, Jian, Liu, Xingguo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148003/
https://ncbi.nlm.nih.gov/pubmed/30237514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1009-8
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