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Unexpected Syntheses of seco-Cyclopropyltetrahydroquinolines From a Radical 5-Exo-Trig Cyclization Reaction: Analogs of CC-1065 and the Duocarmycins

Analogs of the seco-cyclopyrroloindoline (seco-CPI), the DNA alkylation pharmacophore of CC-1065 and the duocarmycins, can be prepared through a 5-exo-trig radical cyclization of a free radical and a 3-chloro-2-allylic moiety. This manuscript reports an unexpected discovery that, depending on the st...

詳細記述

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書誌詳細
出版年:Molecules
主要な著者: Pati, Hari, Howard, Tiffany, Townes, Heather, Lingerfelt, Brian, McNulty, LuAnne, Lee, Moses
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2004
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147511/
https://ncbi.nlm.nih.gov/pubmed/18007417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/90300125
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