Exogenous C-type natriuretic peptide restores normal growth and prevents early growth plate closure in its deficient rats

Signaling by C-type natriuretic peptide (CNP) and its receptor, natriuretic peptide receptor-B, is a pivotal stimulator of endochondral bone growth. We recently developed CNP knockout (KO) rats that exhibit impaired skeletal growth with early growth plate closure. In the current study, we further ch...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hirota, Keisho, Furuya, Mayumi, Morozumi, Naomi, Yoshikiyo, Kazunori, Yotsumoto, Takafumi, Jindo, Toshimasa, Nakamura, Ryuichi, Murakami, Koichiro, Ueda, Yohei, Hanada, Takeshi, Sade, Hiroko, Yoshida, Sayaka, Enomoto, Kei, Kanai, Yugo, Yamauchi, Ichiro, Yamashita, Takafumi, Ueda-Sakane, Yoriko, Fujii, Toshihito, Yasoda, Akihiro, Inagaki, Nobuya
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147488/
https://ncbi.nlm.nih.gov/pubmed/30235256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0204172
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