Foramen magnum stenosis and midface hypoplasia in C-type natriuretic peptide-deficient rats and restoration by the administration of human C-type natriuretic peptide with 53 amino acids

C-type natriuretic peptide (CNP)-knockout (KO) rats exhibit impaired skeletal growth, with long bones shorter than those in wild-type (WT) rats. This study compared craniofacial morphology in the CNP-KO rat with that in the Spontaneous Dwarf Rat (SDR), a growth hormone (GH)-deficient model. The effe...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Yotsumoto, Takafumi, Morozumi, Naomi, Furuya, Mayumi, Fujii, Toshihito, Hirota, Keisho, Ueda, Yohei, Nakao, Kazumasa, Yamanaka, Shigeki, Yoshikiyo, Kazunori, Yoshida, Sayaka, Nishimura, Tomonari, Abe, Yasuyuki, Jindo, Toshimasa, Ogasawara, Hiroyuki, Yasoda, Akihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532844/
https://ncbi.nlm.nih.gov/pubmed/31120905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216340
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