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Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4-dihydropyrazol-3-one Nucleosides

2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by (1)H and (13)C-NMR spectroscopy. Glucoside 3b shows an in vitro IC(50) value of 16.4 µM against proliferation of the human promyelotic leukemia (HL60) cel...

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Bibliografski detalji
Izdano u:Molecules
Glavni autori: Abdou, Ibrahim M., Saleh, Ayman M., Zohdi, Hussein F.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2004
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147422/
https://ncbi.nlm.nih.gov/pubmed/18007415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/90300109
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