JAG1 overexpression contributes to Notch1 signaling and the migration of HTLV-1-transformed ATL cells

BACKGROUND: HTLV-1 is a retrovirus that infects over 20 million people worldwide and is responsible for the hematopoietic malignancy adult T cell leukemia (ATL). We previously demonstrated that Notch is constitutively activated in ATL cells. Activating genetic mutations were found in Notch; however,...

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Bibliografiske detaljer
Udgivet i:J Hematol Oncol
Main Authors: Bellon, Marcia, Moles, Ramona, Chaib-Mezrag, Hassiba, Pancewicz, Joanna, Nicot, Christophe
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146899/
https://ncbi.nlm.nih.gov/pubmed/30231940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-018-0665-6
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