Histone Citrullination Represses MicroRNA Expression, Resulting in Increased Oncogene mRNAs in Somatolactotrope Cells

Peptidylarginine deiminase (PAD) enzymes convert histone arginine residues into citrulline to modulate chromatin organization and gene expression. Although PADs are expressed in anterior pituitary gland cells, their functional role and expression in pituitary adenomas are unknown. To begin to addres...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Cell Biol
Main Authors: DeVore, Stanley B., Young, Coleman H., Li, Guangyuan, Sundararajan, Anitha, Ramaraj, Thiruvarangan, Mudge, Joann, Schilkey, Faye, Muth, Aaron, Thompson, Paul R., Cherrington, Brian D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146832/
https://ncbi.nlm.nih.gov/pubmed/29987187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00084-18
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