Histone Citrullination Represses MicroRNA Expression, Resulting in Increased Oncogene mRNAs in Somatolactotrope Cells

Peptidylarginine deiminase (PAD) enzymes convert histone arginine residues into citrulline to modulate chromatin organization and gene expression. Although PADs are expressed in anterior pituitary gland cells, their functional role and expression in pituitary adenomas are unknown. To begin to addres...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: DeVore, Stanley B., Young, Coleman H., Li, Guangyuan, Sundararajan, Anitha, Ramaraj, Thiruvarangan, Mudge, Joann, Schilkey, Faye, Muth, Aaron, Thompson, Paul R., Cherrington, Brian D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146832/
https://ncbi.nlm.nih.gov/pubmed/29987187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00084-18
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