Inhibition of NKCC1 Modulates Alveolar Fluid Clearance and Inflammation in Ischemia-Reperfusion Lung Injury via TRAF6-Mediated Pathways

Background: The expression of Na-K-2Cl cotransporter 1 (NKCC1) in the alveolar epithelium is responsible for fluid homeostasis in acute lung injury (ALI). Increasing evidence suggests that NKCC1 is associated with inflammation in ALI. We hypothesized that inhibiting NKCC1 would attenuate ALI after i...

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Publicat a:Front Immunol
Autors principals: Shen, Chih-Hao, Lin, Jr-Yu, Chang, Yung-Lung, Wu, Shu-Yu, Peng, Chung-Kan, Wu, Chin-Pyng, Huang, Kun-Lun
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146090/
https://ncbi.nlm.nih.gov/pubmed/30271405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02049
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