Inhibition of NKCC1 Modulates Alveolar Fluid Clearance and Inflammation in Ischemia-Reperfusion Lung Injury via TRAF6-Mediated Pathways

Background: The expression of Na-K-2Cl cotransporter 1 (NKCC1) in the alveolar epithelium is responsible for fluid homeostasis in acute lung injury (ALI). Increasing evidence suggests that NKCC1 is associated with inflammation in ALI. We hypothesized that inhibiting NKCC1 would attenuate ALI after i...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Shen, Chih-Hao, Lin, Jr-Yu, Chang, Yung-Lung, Wu, Shu-Yu, Peng, Chung-Kan, Wu, Chin-Pyng, Huang, Kun-Lun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146090/
https://ncbi.nlm.nih.gov/pubmed/30271405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02049
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