Soluble Aβ42 Acts as Allosteric Activator of the Core Cholinergic Enzyme Choline Acetyltransferase

Two major questions in the field of Alzheimer-type dementia remain elusive. One is the native function of amyloid-β (Aβ) peptides and the other is an early deficit in the central cholinergic network. Nevertheless, recent evidence suggests that Aβ peptides are involved in the regulation of acetylchol...

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Vydáno v:Front Mol Neurosci
Hlavní autoři: Kumar, Amit, Lana, Erica, Kumar, Rajnish, Lithner, Christina Unger, Darreh-Shori, Taher
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146036/
https://ncbi.nlm.nih.gov/pubmed/30271321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00327
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