Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade

Oligodendrocytes are highly vulnerable to glutamate excitotoxicity, a central mechanism involved in tissue damage in Multiple Sclerosis (MS). Sustained activation of AMPA receptors in rat oligodendrocytes induces cytosolic calcium overload, mitochondrial depolarization, increase of reactive oxygen s...

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Bibliografske podrobnosti
izdano v:Front Mol Neurosci
Main Authors: Canedo-Antelo, Manuel, Serrano, Mari Paz, Manterola, Andrea, Ruiz, Asier, Llavero, Francisco, Mato, Susana, Zugaza, José Luis, Pérez-Cerdá, Fernando, Matute, Carlos, Sánchez-Gómez, María Victoria
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146035/
https://ncbi.nlm.nih.gov/pubmed/30271323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00333
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