P2X(7) Receptor Blockade Prevents ATP Excitotoxicity in Oligodendrocytes and Ameliorates Experimental Autoimmune Encephalomyelitis

Oligodendrocyte death and demyelination are hallmarks of multiple sclerosis (MS). Here we show that ATP signaling can trigger oligodendrocyte excitotoxicity via activation of calcium-permeable P2X(7) purinergic receptors expressed by these cells. Sustained activation of P2X(7) receptors in vivo caus...

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Bibliografiset tiedot
Julkaisussa:J Neurosci
Päätekijät: Matute, Carlos, Torre, Iratxe, Pérez-Cerdá, Fernando, Pérez-Samartín, Alberto, Alberdi, Elena, Etxebarria, Estibaliz, Arranz, Amaia M., Ravid, Rivka, Rodríguez-Antigüedad, Alfredo, Sánchez-Gómez, MaríaVictoria, Domercq, María
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for Neuroscience 2007
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673129/
https://ncbi.nlm.nih.gov/pubmed/17728465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0579-07.2007
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