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Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300

Ageing is the primary risk factor for osteoarthritis (OA). A decline in the ageing-associated process of autophagy is suggested as a potential contributor to OA development. Polyamines such as spermidine decrease during ageing, contributing to impaired autophagy and reduced cellular function. Howeve...

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Détails bibliographiques
Publié dans:Exp Mol Med
Auteurs principaux: Sacitharan, Pradeep K., Lwin, Seint, Gharios, George Bou, Edwards, James R.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145946/
https://ncbi.nlm.nih.gov/pubmed/30232322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-018-0149-3
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