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Spermidine induces autophagy by inhibiting the acetyltransferase EP300

Several natural compounds found in health-related food items can inhibit acetyltransferases as they induce autophagy. Here we show that this applies to anacardic acid, curcumin, garcinol and spermidine, all of which reduce the acetylation level of cultured human cells as they induce signs of increas...

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Detalles Bibliográficos
Publicado en:Cell Death Differ
Autores principales: Pietrocola, F, Lachkar, S, Enot, D P, Niso-Santano, M, Bravo-San Pedro, J M, Sica, V, Izzo, V, Maiuri, M C, Madeo, F, Mariño, G, Kroemer, G
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326581/
https://ncbi.nlm.nih.gov/pubmed/25526088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.215
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