Spermidine induces autophagy by inhibiting the acetyltransferase EP300

Several natural compounds found in health-related food items can inhibit acetyltransferases as they induce autophagy. Here we show that this applies to anacardic acid, curcumin, garcinol and spermidine, all of which reduce the acetylation level of cultured human cells as they induce signs of increas...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Pietrocola, F, Lachkar, S, Enot, D P, Niso-Santano, M, Bravo-San Pedro, J M, Sica, V, Izzo, V, Maiuri, M C, Madeo, F, Mariño, G, Kroemer, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326581/
https://ncbi.nlm.nih.gov/pubmed/25526088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.215
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