Spermidine induces autophagy by inhibiting the acetyltransferase EP300

Several natural compounds found in health-related food items can inhibit acetyltransferases as they induce autophagy. Here we show that this applies to anacardic acid, curcumin, garcinol and spermidine, all of which reduce the acetylation level of cultured human cells as they induce signs of increas...

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Опубликовано в: :Cell Death Differ
Главные авторы: Pietrocola, F, Lachkar, S, Enot, D P, Niso-Santano, M, Bravo-San Pedro, J M, Sica, V, Izzo, V, Maiuri, M C, Madeo, F, Mariño, G, Kroemer, G
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Original Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326581/
https://ncbi.nlm.nih.gov/pubmed/25526088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.215
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