Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function

The ApoE4 allele is associated with increased risk of small vessel disease, which is a cause of vascular cognitive impairment. Here, we report that mice with targeted replacement (TR) of the ApoE gene with human ApoE4 have reduced neocortical cerebral blood flow compared to ApoE3-TR mice, an effect...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Koizumi, Kenzo, Hattori, Yorito, Ahn, Sung Ji, Buendia, Izaskun, Ciacciarelli, Antonio, Uekawa, Ken, Wang, Gang, Hiller, Abigail, Zhao, Lingzhi, Voss, Henning U., Paul, Steven M., Schaffer, Chris, Park, Laibaik, Iadecola, Costantino
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145902/
https://ncbi.nlm.nih.gov/pubmed/30232327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06301-2
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