Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

A diet rich in salt is linked to an increased risk of cerebrovascular diseases and dementia, but it remains unclear how dietary salt harms the brain. We report that, in mice, excess dietary salt suppresses resting cerebral blood flow and endothelial function, leading to cognitive impairment. The eff...

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Publicat a:Nat Neurosci
Autors principals: Faraco, Giuseppe, Brea, David, Garcia-Bonilla, Lidia, Wang, Gang, Racchumi, Gianfranco, Chang, Haejoo, Buendia, Izaskun, Santisteban, Monica M., Segarra, Steven G., Koizumi, Kenzo, Sugiyama, Yukio, Murphy, Michelle, Voss, Henning, Anrather, Joseph, Iadecola, Costantino
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207376/
https://ncbi.nlm.nih.gov/pubmed/29335605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-017-0059-z
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