Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

A diet rich in salt is linked to an increased risk of cerebrovascular diseases and dementia, but it remains unclear how dietary salt harms the brain. We report that, in mice, excess dietary salt suppresses resting cerebral blood flow and endothelial function, leading to cognitive impairment. The eff...

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I publikationen:Nat Neurosci
Huvudupphovsmän: Faraco, Giuseppe, Brea, David, Garcia-Bonilla, Lidia, Wang, Gang, Racchumi, Gianfranco, Chang, Haejoo, Buendia, Izaskun, Santisteban, Monica M., Segarra, Steven G., Koizumi, Kenzo, Sugiyama, Yukio, Murphy, Michelle, Voss, Henning, Anrather, Joseph, Iadecola, Costantino
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207376/
https://ncbi.nlm.nih.gov/pubmed/29335605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-017-0059-z
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