Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway

BACKGROUND: Matrine, a traditional Chinese medicine, has recently been shown to have antitumor properties in diverse cancer cells. Here, we explored the effect of matrine on human glioblastoma multiforme (GBM) cells. METHODS: Glioblastoma multiforme cell lines were treated with matrine to assess pro...

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Bibliografiske detaljer
Udgivet i:Cancer Med
Main Authors: Zhou, Wenjing, Wang, Jiwei, Qi, Qichao, Feng, Zichao, Huang, Bin, Chen, Anjing, Zhang, Di, Li, Wenjie, Zhang, Qing, Bjerkvig, Rolf, Li, Xingang, Wang, Jian
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143938/
https://ncbi.nlm.nih.gov/pubmed/30079478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1720
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