Nrf2-dependent antioxidant response mediated the protective effect of tanshinone IIA on doxorubicin-induced cardiotoxicity

Doxorubicin (DOX), a potent and widely used anticancer agent, can give rise to severe cardiotoxicity that limits its clinical use by inducing oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the central regulator of cellular responses to electrophilic/oxidative stress, which s...

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Vydáno v:Exp Ther Med
Hlavní autoři: Guo, Zhaohui, Yan, Miao, Chen, Lei, Fang, Pingfei, Li, Zhihua, Wan, Zimeng, Cao, Sisi, Hou, Zhenyan, Wei, Shanshan, Li, Wenqun, Zhang, Bikui
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143869/
https://ncbi.nlm.nih.gov/pubmed/30233680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2018.6614
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