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Elevated leptin during diet-induced obesity reduces the efficacy of tumor immunotherapy

Various malignancies are reproducibly cured in mouse models, but most cancer immunotherapies show objective responses in a fraction of treated patients. One reason for this disconnect may be the use of young, lean mice lacking immune altering co-morbidities present in cancer patients. While many can...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Murphy, Katherine A., James, Britnie R., Sjaastad, Frances V., Kucaba, Tamara A., Kim, Hyunjoon, Brincks, Erik L., Chua, Streamson C., Wilber, Andrew, Griffith, Thomas S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143418/
https://ncbi.nlm.nih.gov/pubmed/30135180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701738
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