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Protecting Encapsulin Nanoparticles with Cysteine-Knot Miniproteins

[Image: see text] A big hurdle for the use of protein-based drugs is that they are easily degraded by proteases in the human body. In an attempt to solve this problem, we show the possibility to functionalize TM encapsulin nanoparticles with an mEETI-II knottin miniprotein from the cysteine-stabiliz...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Pharm
Hauptverfasser: Klem, Robin, de Ruiter, Mark V., Cornelissen, Jeroen J.L.M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2018
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143317/
https://ncbi.nlm.nih.gov/pubmed/30047270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00630
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