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Protecting Encapsulin Nanoparticles with Cysteine-Knot Miniproteins

[Image: see text] A big hurdle for the use of protein-based drugs is that they are easily degraded by proteases in the human body. In an attempt to solve this problem, we show the possibility to functionalize TM encapsulin nanoparticles with an mEETI-II knottin miniprotein from the cysteine-stabiliz...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Klem, Robin, de Ruiter, Mark V., Cornelissen, Jeroen J.L.M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143317/
https://ncbi.nlm.nih.gov/pubmed/30047270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00630
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