The conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer

Conservation over three mammalian genera—the mouse, rat, and human—has been found for a subset of the transcripts whose level differs between the adenoma and normal epithelium of the colon. Pde4b is one of the triply conserved transcripts whose level is enhanced both in the colonic adenoma and in th...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Pleiman, Jennifer K., Irving, Amy A., Wang, Zhishi, Toraason, Erik, Clipson, Linda, Dove, William F., Deming, Dustin A., Newton, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143270/
https://ncbi.nlm.nih.gov/pubmed/30188895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007611
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