DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies

IMPORTANCE: Depressive disorders arise from a combination of genetic and environmental risk factors. Epigenetic disruption provides a plausible mechanism through which gene-environment interactions lead to depression. Large-scale, epigenome-wide studies on depression are missing, hampering the ident...

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Bibliografski detalji
Izdano u:JAMA Psychiatry
Glavni autori: Story Jovanova, Olivera, Nedeljkovic, Ivana, Spieler, Derek, Walker, Rosie M., Liu, Chunyu, Luciano, Michelle, Bressler, Jan, Brody, Jennifer, Drake, Amanda J., Evans, Kathryn L., Gondalia, Rahul, Kunze, Sonja, Kuhnel, Brigitte, Lahti, Jari, Lemaitre, Rozenn N., Marioni, Riccardo E., Swenson, Brenton, Himali, Jayandra Jung, Wu, Hongsheng, Li, Yun, McRae, Allan F., Russ, Tom C., Stewart, James, Wang, Zhiying, Zhang, Guosheng, Ladwig, Karl-Heinz, Uitterlinden, Andre G., Guo, Xiuqing, Peters, Annette, Räikkönen, Katri, Starr, John M., Waldenberger, Melanie, Wray, Naomi R., Whitsel, Eric A., Sotoodehnia, Nona, Seshadri, Sudha, Porteous, David J., van Meurs, Joyce, Mosley, Thomas H., McIntosh, Andrew M., Mendelson, Michael M., Levy, Daniel, Hou, Lifang, Eriksson, Johan G., Fornage, Myriam, Deary, Ian J., Baccarelli, Andrea, Tiemeier, Henning, Amin, Najaf
Format: Artigo
Jezik:Inglês
Izdano: American Medical Association 2018
Teme:
Original Investigation
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142917/
https://ncbi.nlm.nih.gov/pubmed/29998287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamapsychiatry.2018.1725
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