Biochanin a Enhances the Defense Against Salmonella enterica Infection Through AMPK/ULK1/mTOR-Mediated Autophagy and Extracellular Traps and Reversing SPI-1-Dependent Macrophage (MΦ) M2 Polarization

A novel treatment regimen for bacterial infections is the pharmacological enhancement of the host's immune defenses. We demonstrated that biochanin A (BCA), an isoflavone constituent in some plants, could enhance both intra- and extracellular bactericidal activity of host cells. First, BCA coul...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Zhao, Xingchen, Tang, Xudong, Guo, Na, An, Yanan, Chen, Xiangrong, Shi, Ce, Wang, Chao, Li, Yan, Li, Shulin, Xu, Hongyue, Liu, Mingyuan, Wang, Yang, Yu, Lu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Cellular and Infection Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142880/
https://ncbi.nlm.nih.gov/pubmed/30271755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2018.00318
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