Cryo-EM structure of human mitochondrial trifunctional protein

The mitochondrial trifunctional protein (TFP) catalyzes three reactions in the fatty acid β-oxidation process. Mutations in the two TFP subunits cause mitochondrial trifunctional protein deficiency and acute fatty liver of pregnancy that can lead to death. Here we report a 4.2-Å cryo-electron micros...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Liang, Kai, Li, Ningning, Wang, Xiao, Dai, Jianye, Liu, Pulan, Wang, Chu, Chen, Xiao-Wei, Gao, Ning, Xiao, Junyu
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142257/
https://ncbi.nlm.nih.gov/pubmed/29915090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801252115
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