טוען...
Computational design of orthogonal membrane receptor-effector switches for rewiring signaling pathways
Membrane receptors regulate numerous intracellular functions. However, the molecular underpinnings remain poorly understood because most receptors initiate multiple signaling pathways through distinct interaction interfaces that are structurally uncharacterized. We present an integrated computationa...
שמור ב:
| הוצא לאור ב: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6142221/ https://ncbi.nlm.nih.gov/pubmed/29915030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718489115 |
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