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Computational design of orthogonal nucleoside kinases
We report the computational enzyme design of an orthogonal nucleoside analog kinase for 3’-deoxythymidine. The best kinase variant shows a 8500-fold change in substrate specificity, resulting from a 4.6-fold gain in catalytic efficiency for the nucleoside analog and a 2000-fold decline for the nativ...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3733048/ https://ncbi.nlm.nih.gov/pubmed/20959903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0cc02961k |
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